DEVELOPMENT OF THE ACELLULAR DERMAL MATRIX AND EXPERIMENTAL SUBSTANTIATION OF ITS USE IN THE ANTERIOR ABDOMINAL WALL HERNIA REPAIR

Development of the Acellular Dermal Matrix and Experimental Substantiation of Its Use in the Anterior Abdominal Wall hernia Repair

Objective: To develop a biological implant that is an acellular dermal matrix (ADM), evaluate its use as a support material in tensionfree hernioplasty for ventral hernia, and compare it to that of the commercially available implant PermacolTM.Materials and methods: ADM was derived from the porcine dermis (Landrace breed) decellularized using deter

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Variants of the industrially relevant protease KP-43 with suppressed activity under alkaline conditions developed using expanded genetic codes

In the present study, we attempted Hemp Wicks to control the pH profile of the catalytic activity of the industrially relevant alkaline protease KP-43, by incorporating 3-nitro-l-tyrosine and 3-chloro-l-tyrosine at and near the catalytic site.Thirty KP-43 variants containing these non-natural amino acids at the specific positions were synthesized i

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Leukemia Mediated Endothelial Cell Activation Modulates Leukemia Cell Susceptibility to Chemotherapy through a Positive Feedback Loop Mechanism.

In acute myeloid leukemia (AML), the chances of achieving disease-free survival are low.Studies have demonstrated a supportive role of endothelial cells (ECs) in normal hematopoiesis.Here we show that similar intercellular relationships exist in leukemia.We demonstrate that leukemia cells themselves initiate these interactions by directly modulatin

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Study on autonomous braking control system based on motion prediction considering overtaking motion of cyclists

This paper presents motion prediction model of cyclist based on potential field for a hazard-anticipatory collision avoidance braking system to enhance the collision avoidance performance and secure the smoothness of driving.The Breast Pad target situation is chosen as the scene that a cyclist overtakes a pedestrian or another slowcyclist based on

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